A systems approach to the classification of genes impacting the cardiovascular phenome

Tom Gaunt, Ian Day

Tom Gaunt and Ian Day along with Colin Campbell (Eng Maths, Bristol) and Juan-Pablo Casas (LSHTM) have been awarded £310,320 by the UK Medical Research Council to develop systems approaches to the classification of genes impacting the cardiovascular phenome. The grant will start 2010 and run until 2013.

Prenatal alcohol exposure, childhood development and teenage drinking: a study of trans-generational effects

Luisa Zuccolo

Luisa Zuccolo has been awarded £417,352 by the UK Medical Research Council. The grant will start in Sept 2010 and will run until August 2014.

Life course inequalities in asthma: estimating its burden and understanding its aetiology

Bruna Galobardes

Bruna Galobardes has been awarded £329,264 by the Wellcome Trust. The grant will start on 1st April 2010 and will run until 31st March 2015.

Survey of Hepatitis C. Prevalence amongst prisoners in Scotland.

Matthew Hickman

Matthew Hickman along with A Taylor (PI), S Cameron, E Allen and D Best have been awarded £391,548 by the Scottish Prison Service. The grant will start in 2010 and will run until 2012.

Evaluating population-based screening for localised prostate cancer in the United Kingdom: the CAP (Comparison Arm for ProtecT study

Professor Richard Martin

Professor Richard Martin and colleagues Jenny Donovan, Freddie Hamdy [Oxford], David Neal [Cambridge], Sian Noble, Athene Lane, Jonathan Sterne, Chris Metcalfe, Yoav Ben-Shlomo, Stephen Oliver [York], Jane Wolstenholme [Oxford], Peter Brindle and Simon Evans have been awarded £1.05 million by CRUK. The start date is January 2010 for 3 years.

Developing and disseminating robust methods for handling missing data in epidemiological studies

Dr Kate Tilling

Dr Kate Tilling (PI) and Jonathan Sterne along with colleagues at the London School of Hygiene and Tropical Medicine (James Carpenter and Mike Kenward) and Ghent University (Stijn Vansteelandt) have been awarded £481,663 by the MRC to develop and disseminate robust methods for handling missing data in epidemiological studies, with particular focus on the application of these methods in longitudinal studies (including ALSPAC). The grant started on the 1st October 2009 and will run until 30th September 2012.

Making diagnostic systematic reviews fit for purpose: improving decision making in the NHS

Dr Penny Whiting

Dr Penny Whiting and Professor Jonathan Sterne have been awarded £703,210 by the MRC. The grant started on 1 May 2009 and will run until 30 April 2012.

Influences on psychosocial and physical health in rarly adulthood

Dr John Macleod

Dr John Macleod has been awarded £1,686,058 by the Wellcome Trust. The grant started on 1st April 2009 and will run until 31 March 2014.

The ConDuCT Hub

Professor Jane Blazeby

Jane Blazeby and co-applicants Jenny Donovan, Ali Heawood (Community Based Medicine), Tony Ades (Community Based Medicine), Nicky Welton (Community Based Medicine), Chris Metcalfe, Sian Noble and Athene Lane have been awarded £1,908,156 for five years from the Medical Research Council to establish The ConDuCT Hub. This is regional focus for high-quality, cutting-edge methodology research in randomised clinical trials. The ConDuCT Hub, (COllaboration and iNnovation in DifficUlt and complex randomised Controlled Trials) Hub will bring together and reinforce existing strengths in methodological research as well as fostering new lines of research. The Hub network with other trials Hub to form a national methodological platform for clinical trials research. It started in April 2009 and will run for 5 years.

EU FP7 programme for Developing a Child Cohort Research Strategy for Europe

Professor Debbie Lawlor

Debbie Lawlor, together with colleagues from Bristol (Patricia Lucas and George Davey Smith) and from Spain, Norway, Denmark, Italy and the Netherlands have been awarded EU 1,490,124 by the EU FP7 programme for Developing a Child Cohort Research Strategy for Europe. The grant will run from 2009 until 2012.

Genome-wide association study of maternal pregnancy phenotypes and later-life maternal and offspring vascular and metabolic phenotypes in ALSPAC

Professor Debbie Lawlor

Debbie Lawlor (PI) and colleagues at Bristol University (George Davey Smith, David Evans, Kate Tilling, Sue Ring, Nic Timpson, Beate Glaser, Tom Gaunt & Wendy McArdle) and CNG Paris (Mark Lathrop) have been awarded £2,306,620 by the Wellcome Trust to complete a genome-wide association study of maternal pregnancy phenotypes and later-life maternal and offspring vascular and metabolic phenotypes in ALSPAC. The grant will run from 2009 until 2011.

Follow-up for the British Women's Heart and Health Study

Professor Debbie Lawlor

Debbie Lawlor, together with colleagues from London (Shah Ebrahim (PI), Peter Whincup, Richard Morris, Hanna Kuper, Jaun-Pablo Casas & Goya Wannamethee have been awarded two grants - £538, 932 from the Department of Health and £308,528 from the British Heart Foundation to continue following up the British Women's Heart and Health Study. Both grants will run from 2009 until 2012.

Examining the utility of biomarkers for non-alcoholic fatty liver disease adolescents

Professor Debbie Lawlor

Professor Debbie Lawlor, together with other colleagues from the Department (Abigail Fraser, Jonathan Sterne and George Davey Smith), the United Bristols NHS Trust (Mark Callaway) and colleagues at the University of Newcastle (Chris Day) and University of Glasgow (Naveed Sattar) has been awarded £548,636 by the Medical Research Council to examine the utility of biomarkers for non-alcoholic fatty liver disease in adolescents. The grant will run from April 2009 to March 2012.

Cluster randomised controlled trial to test the effectiveness of educational intervention to promote hand washing in reducing absenteeism in school

Professor Rona Campbell

Professor Rona Campbell has been awarded £292,568 by the Department of Health. The grant started on 1st Janury 2009 and will run until 31 December 2010.

DECIPHer Centre

Professor Rona Campbell

Professor Rona Campbell and co-applicants Jenny Donovan, David Gunnell and Matt Hickman, and collaborators Yoav Ben-Shlomo, Debbie Lawlor, Will Hollingworth, John Macleod, Jonathan Sterne, Patrick Horner, Richard Martin, Sara Brookes, and also Ashley Cooper and Angie Page (Exercise, Nutrition and Health Sciences) and Tim Peters and Alan Emond (COBM) together with Cardiff and Swansea have been awarded £5 million by the ESRC for a Public Health Research Centre (DECIPHer - Development and Evaluation of Complex Interventions for Public Health Improvement). The Centre started on 1st January 2009 and will run until 31 December 2013.

A feasibility randomised trial in oesophageal squamous cell cancer

Professor Jane Blazeby

Jane Blazeby, Mike Griffin (Newcastle), Tom Crosby (Velindre, Cardiff), Sara Brookes, Alan Montgomery (Community Based Medicine, Bristol University), Will Hollingworth and Professor Jenny Donovan have been awarded £249,619 from the NIHR Research for Patient Benefit Scheme to undertake a feasibility randomised trial in oesophageal squamous cell cancer. This study will examine whether a full multi-centre trial is feasibile (comparing chemoradiotherapy with chemotherapy and surgery). It will also establish methods for recruiting patients into trials from multi-disciplinary team meetings and best methods for communicating outcomes to patients eligible for randomisation. It is due to run for 24 months starting in 2009.

Improving Patients' experience and outcome of total joint replacement

Rachael Gooberman-Hill

Rachael Gooberman-Hill, Andy Beswick, Jeremy Horwood, Sian Noble and Sara Brookes in collaboration with Asley Blom (PI) and colleagues at The Avon Orthopaedic Centre (Soutmead) have been awarded £1.977 million by the National Institute for Health Research. The Programme entitled 'Improving Patients' experience and outcome of total joint replacement' will be held at North Bristol NHS Trust and will run for 5 years.

Evaluation of Integrated Drug Treatment System in Prisons

Dr Matthew Hickman

Matthew Hickman and colleagues M Farrell (King's), J Marsdon (King's), J King (Manchester) and C Metcalfe (Bristol) have been funded by the Home Office for the "Evaluation of Integrated Drug Treatment System in Prisons". The award is for £612,589 and started in 2009 and will run until 2012.

Development and evaluation of interventions for the prevention of childhood obesity in a multi-ethnic population: the Born in Bradford NHS Research Programme

Professor Debbie Lawlor

Professor Debbie Lawlor and colleagues including J Wright (PI) have been awarded £1,999,300 by the National Institute for Health Research. The funding started in 2008 and will run until 2012.

Measurement and modelling of functional trajectories across the life course (cross-unit appintments)

Professor Debbie Lawlor

Professor Debbie Lawlor, R Hardy (PI), F Matthews, D Kuh, Aihie Sayer and M Benzeval have been awarded £280,134 from the Medical Research Council. The funding started in 2008 and will run until 2011.

Public Health Consequences of Modifiable Maternal Exposures; Offspring Obesity and Cognitive Health in Two Cohorts in the UK and Brazil

Dr Marie-Jo Brion

Dr Marie-Jo Brion has been awarded £250,000 for a Sir Henry Wellcome Postdoctoral Fellowship. The fellowship commences on 1st October 2008 until 30th September 2012.

South Asia Centre for Population Health Research

Professor George Davey Smith and Professor Shah Ebrahim (London School of Hygiene and Tropical Medicine) and colleagues have been awarded £4,500,000 by the Wellcome Trust. The grant is due to start in October 2008 until September 2013.

Milk, dairy products, and calcium intakes in children: prospective associations with body mass composition measured using dual-energy X-ray absorptiometry

Kirstin Newby (Boston), Professor Andy Ness, Dr Pauline Emmett, Mrs Kate Northstone, Dr Li Benfield and Professor George Davey Smith have been awarded $351,952 by the National Institute of Health. The grant started in July 2008 until June 2011.

ProtecT Study

Professor Jenny Donovan

Professor Jenny Donovan has been awarded £14.4 million from the NHS HTA Programme, along with Dr Athene Lane to complete recruitment and for the first five years of follow up for the ProtecT study. The grant started in June 2008 until December 2013.

Association of factors in the folate metabolic pathway with prostate cancer incidence and progression.

Dr Richard Martin

Dr Richard Martin has been awarded £147,971 from the WCRF, along with co-investigators Professor Jenny Donovan, Professor Freddie Hamdy (Sheffield), Professor David Neal (Cambridge), Dr Chris Metcalfe, Dr Athene Lane, Dr Sarah Lewis, Professor George Davey Smith, Professor David Smith (Oxford), Professor Helga Refsum (Norway). The grant started in March 2008 until Feb 2011.

Environmental and genetic determinants of obesity and diabetes in India

Professor George Davey Smith

Professor George Davey Smith, Professor Shah Ebrahim (London School of Hygiene and Tropical Medicine), Professor Ian Day, John Whittaker (LSHTM) and Dr Sanjay Kinra have been awarded £351,136 from the Wellcome Trust. The grant started in January 2008 until December 2010.

The ART Cohort Collaboration (ART-CC). Monitoring and modelling the prognosis of HIV-infected patients in the era of effective antiretroviral therapy.

Professor Jonathan Sterne, Dr Margaret May and Professor Matthias Egger

Professor Jonathan Sterne, Dr Margaret May and Professor Matthias Egger have been awarded £627,144 by the Medical Research Council, together with an international team of collaborators (Dr Jordi Casabona, Dr Dominique Costagliola, Professor Antonella Arminio Monforte, Professor Francois Dabis, Dr Frank de Wolf, Dr Julia del Amo, Professor Gerd Fätkenheuer, Professor John Gill, Dr Jodie Guest, Dr Robert Hogg, Professor Amy Justice, Dr Mari Kitahata, Dr Fiona Lampe, Professor Bruno Ledergerber, Dr Amanda Mocroft, Professor Michael Saag, and Dr Timothy Sterling). For more information about ART-CC, please see www.art-cohort-collaboration.org. The grant started in January 2008 until January 2011.

Molecular, Genetic and Lifecourse Epidemiology

Professor George Davey Smith, Dr Richard Martin and Professor Ian Day

Professor George Davey Smith, Dr Richard Martin and Professor Ian Day have been awarded £2,000,000 for a four-year PhD programme from the Wellcome Trust to provide 3 PhD students per year for 6 years. Although only 21 of these highly coveted awards were made in the Wellcome Trust's latest funding round, a programme in Dynamic Cell Biology was also awarded to the Department of Biochemistry. The two programmes have planned to hold joint training sessions with the aim of fostering collaboration between the two Departments. The programme started in January 2008 until December 2018.

Genetic risk factors for cardiovascular disease in the British Women's Heart and Health Study

Dr Tom Gaunt

Dr Tom Gaunt has been awarded £163,757 from the British Heart Foundation, along with co-investigators Professor Ian Day, Professor Debbie Lawlor, Professor Shah Ebrahim (LSHTM) Professor Yoav Ben-Shlomo, Dr Santiago Rodriguez and Professor George Davey Smith. The grant started on 1st December 2007 until 30th November 2010.

Obstetric, lifestyle and genetic determinants of arteriosclerosis, fat mass, insulin, glucose and lipid levels in women in early middle-age

Professor Debbie Lawlor

Professor Debbie Lawlor has been awarded £882,350 from the British Heart Foundation, along with co-applicants Professor Naveed Sattar, Professor John Deanfield, Dr Kate Tilling, Professor Ian Day, Professor George Davey-Smith and Professor Andy Ness. The grant started on 1 November 2007 until 31 October 2011.

Developing dietary interventions for prostate cancer - systematic reviews and investigations of dietary change

Dr Kerry Avery

Dr Kerry Avery has been awarded £213,867 for an NIHR personal post-doctoral fellowship. The fellowship commenced on 1st October 2007 until 30th September 2011.

Centre for Causal Analyses in Translational Epidemiology (CAiTE)

Professor George Davey Smith, Professor Debbie Lawlor and Professor Ian Day

Professor George Davey Smith (Director) and Professors Debbie A Lawlor and Ian NM Day (Deputy Directors) have been awarded £2,404,380 for an MRC Centre Grant. The grant started in September 2007 until May 2012.

A multi-centre programme of clinical and public health research in support of the National Suicide Prevention Strategy for England

Professor David Gunnell

Professor David Gunnell has been awarded £898,000 from the Department of Health, along with co-investigators Professor Keith Hawton (Oxford), Dr Nav Kapur (Manchester), Dr Jonathan Evans, Professor Jenny Donovan, Dr Frank Margison (Manchester), Dr Susan O'Connor, Dr Damien Longson (Manchester), Dr Julia Verne and Mr David Bradley (Oxford). The grant started in September 2007 until 2011.

Improving mental health in adolescence: risk factors and interventions within the school context

Dr Judi Kidger

Dr Judi Kidger has been awarded £253,643 for an MRC Training Fellowship. The fellowship commenced on 1st October 2006 until 30th September 2011.

ALSPAC: consolidation of a two generation cell line backed resource, for the study of the environment and genetic determinants of health and development from before birth to late puberty

Professor George Davey Smith, Dr Mary Shaw and Dr Kate Tilling

Professor George Davey Smith, Dr Mary Shaw and Dr Kate Tilling have been awarded £8,942,104 by the MRC/Wellcome Trust together with co-cpplicants Professor Andy Ness, Professor Alan Emond, Professor John Henderson, Professor Glyn Lewis, Professor Tim Peters, Professor Paul Burton (Leicester) and Professor Ian Day. ALSPAC: consolidation of a two generation cell line backed resource, for the study of the environment and genetic determinants of health and development from before birth to late puberty. The project started on 1st January 2006 and runs for 5 years.