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Special Seminars

A list of recent Special Seminars can be viewed here.

2011

Thursday 14 July, 4:00pm
Canynge Hall, room LG.08

The seminar is free, and all are welcome without needing to book a place. If you have physical difficulties with stairs, we have a lift to provide access to the upper floors.

Prof. James D Neaton - Biostatistics Division (School of Public Health) and Medicine, Infectious Diseases and International Medicine (Dept. of Medicine), University of Minnesota

HIV Treatment Trials with Clinical Outcomes: the Juice is Worth the Squeeze

HIV treatment trials with morbidity and mortality outcomes are relatively rare. The International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) has recently reported the results of two large clinical outcome trials, SMART, a trial of episodic use of antiretroviral therapy (ART) and ESPRIT, a trial of interleukin-2. The INSIGHT group is also enrolling a large trial on early use of ART called START. The seminar will address: 1) challenges in the implementation and conduct of these global trials; 2) how the findings of SMART and ESPRIT have changed our thinking about the treatment of HIV and use of CD4+ count as a surrogate marker; and 3) why additional clinical outcome studies should be carried out.

Wednesday 31 August, 12:30pm
Oakfield House , room OS6

The seminar is free, and all are welcome without needing to book a place. If you have physical difficulties with stairs, we have a lift to provide access to the upper floors.

Dr. Abraham Aviv - Director of the Hypertension Center at the New Jersey Medical School

Leukocyte Telomere Dynamics and Cardiovascular Aging

Leukocyte telomere length (LTL) is a complex human genetic trait. Its dynamics (birth LTL and its age-dependent shortening afterward) reflect hematopoietic stem cell (HSC) telomere dynamics. Accordingly, HSC telomere biology might play a role in human aging, given that LTL is associated with atherosclerosis in adults and survival in the elderly. Moreover, LTL is modified by genes, gender, race, epigenetic factors and the environment. The collective impact of these factors on HSC telomere dynamics might partially explain the inter-individual variation in the pace and expression of human aging.